Unveiling the Mystery of Branched-Chain Amino Acids (BCAAs): A Comprehensive Review

Unveiling the Mystery of Branched-Chain Amino Acids (BCAAs): A Comprehensive Review

Introduction: In the ever-evolving landscape of fitness and health products, branched-chain amino acid (BCAA) supplements have gained prominence as a go-to choice for many fitness enthusiasts. The rise in popularity of these supplements can be attributed to their potential benefits in muscle recovery and growth. This review delves into the scientific evidence surrounding the effects of BCAA supplementation on post-exercise muscle recovery and muscle growth, exploring the claims made by exercise supplement companies.

I. The BCAA Craze: Trends and Market Overview As the fitness industry continues to witness unprecedented growth, BCAA supplements have become a staple among consumers seeking to enhance muscle strength, recovery, and overall performance. With the global dietary supplement industry valued at a staggering $122 billion in 2016, the pre-workout supplement market alone reached $12.6 billion in 2019. BCAAs, comprising essential amino acids leucine, isoleucine, and valine, constitute a significant portion of these supplements, promising accelerated muscle recovery and growth.

II. BCAAs for Reducing Muscle Recovery: Navigating the Conflicting Evidence The allure of BCAAs lies in their purported ability to reduce muscle soreness and hasten recovery after exercise. Studies examining indirect biomarkers like creatine kinase (CK) levels and lactate dehydrogenase (LDH) have yielded conflicting results. Some evidence suggests that BCAA supplementation may reduce CK levels and perceived muscle soreness, especially with chronic intake (>10 days) at high doses (>200 mg/kg/day). However, the variability in study designs and outcomes raises questions about the immediate efficacy of BCAAs in short-term use.

III. BCAAs Effect on Protein Synthesis & Muscle Growth: The Controversy Unraveled A central claim surrounding BCAA supplements is their role in enhancing muscle growth and protein synthesis. However, studies employing intravenous infusion of BCAAs have shown a decrease in muscle protein synthesis, leading to a catabolic state. In contrast, oral intake of BCAAs post-exercise demonstrated a higher rate of muscle protein synthesis compared to a placebo. Yet, this increase remains substantially lower than that achieved with whey protein supplementation, indicating potential limitations of BCAAs in promoting significant muscle growth.

IV. Unveiling the Optimal BCAA Supplementation Regimen: Timing is Key Determining the most effective BCAA supplementation regimen poses a significant challenge. Studies suggest that chronic BCAA intake, particularly before exercise (>10 days, >200 mg/kg/day), may mitigate exercise-induced muscle damage. The interplay of frequency, amount, and duration of BCAA supplementation becomes crucial in optimizing their potential benefits.

V. The Road Ahead: Considerations and Caution While current research hints at the potential benefits of BCAAs in muscle recovery and growth, inconsistencies and limitations persist. Addressing the need for all essential amino acids, including non-BCAA components, for optimal muscle protein synthesis raises questions about the exclusive reliance on BCAAs. As the demand for exercise supplements continues to soar, consumers must stay informed about the evolving evidence surrounding BCAA supplementation.

Conclusion: In conclusion, the effects of BCAAs on post-exercise muscle recovery and growth are complex and multifaceted. While BCAAs may offer some benefits in reducing muscle soreness and supporting recovery, the evidence is inconclusive and often conflicting. The discrepancy in outcomes between studies necessitates further research to unlock the full potential of BCAAs. As consumers navigate the vast landscape of exercise supplements, a nuanced understanding of the scientific evidence is crucial for making informed decisions about the efficacy of BCAAs in achieving desired fitness goals.

 

References:


1. Estoche, J. M., Jacinto, J. L., Roveratti, M. C., Gabardo, J. M., Buzzachera, C. F., de
Oliveira, E. P., Ribeiro, A. S., da Silva, R. A., & Aguiar, A. F. (2019). Branched-chain
amino acids do not improve muscle recovery from resistance exercise in untrained young
adults. Amino acids, 51(9), 1387–1395.
https://doi-org.ezproxy.gvsu.edu/10.1007/s00726-019-02776-5
2. Farhana, A., & Lappin, S. (2021, May 7). Biochemistry, lactate dehydrogenase -
statpearls - NCBI ... Biochemistry, Lactate Dehydrogenase. Retrieved April 14, 2022,
from https://www.ncbi.nlm.nih.gov/books/NBK557536/
3. Fouré, A., & Bendahan, D. (2017). Is Branched-Chain Amino Acids Supplementation an
Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic
Review. Nutrients, 9(10), 1047. https://doi.org/10.3390/nu9101047
4. George, M. D., Baker, J. F., & McGill, N.-K. (2016, August). Creatine kinase in the U.S.
population: Impact of... : Medicine. LWW Journals. Retrieved April 17, 2022, from
https://journals.lww.com/md-journal/fulltext/2016/08160/creatine_kinase_in_the_u_s__p
opulation__impact_of.12.aspx
5. Hall, E. C. R., Semenova, E. A., Bondareva, E. A., Andryushchenko, L. B., Larin, A. K.,
Cięszczyk, P., Generozov, E. V ., et al. (2022). Association of Genetically Predicted
BCAA Levels with Muscle Fiber Size in Athletes Consuming Protein. Genes, 13(3), 397.
MDPI AG. Retrieved from http://dx.doi.org/10.3390/genes13030397
6. Hormoznejad, R., Zare Javid, A. & Mansoori, A. (2019). Effect of BCAA
supplementation on central fatigue, energy metabolism substrate and muscle damage to
the exercise: a systematic review with meta-analysis. Sport Sci Health 15, 265–279.
https://doi.org/10.1007/s11332-019-00542-4
7. Jackman, S. R., Witard, O. C., Philp, A., Wallis, G. A., Baar, K., & Tipton, K. D. (2017).
Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis
Following Resistance Exercise in Humans. Frontiers in physiology, 8, 390.
https://doi.org/10.3389/fphys.2017.00390
8. Jankovic, J. (2022). Creatine kinase. Creatine Kinase - an overview | ScienceDirect
Topics. Retrieved April 14, 2022, from
https://www.sciencedirect.com/topics/neuroscience/creatine-kinase
9. Khemtong, C., Kuo, C. H., Chen, C. Y ., Jaime, S. J., & Condello, G. (2021). Does
Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage
16
Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of
Randomized Controlled Trials. Nutrients, 13(6), 1880.
https://doi.org/10.3390/nu13061880
10. Matthews D. E. (2007). An overview of phenylalanine and tyrosine kinetics in humans.
The Journal of nutrition, 137(6 Suppl 1), 1549S–1575S.
https://doi.org/10.1093/jn/137.6.1549S
11. Pre-workout supplements market size: Industry report, 2027. Pre-workout Supplements
Market Size | Industry Report, 2027. (2020, March). Retrieved April 14, 2022, from
https://www.grandviewresearch.com/industry-analysis/pre-workout-supplements-market#
:~:text=The%20global%20pre%2Dworkout%20supplements%20market%20size%20was
%20estimated%20at,pre%2Dworkout%20supplements%20market%20growth%3F
12. Santos, C. S., & Nascimento, F. (2019). Isolated branched-chain amino acid intake and
muscle protein synthesis in humans: a biochemical review. Einstein (Sao Paulo, Brazil),
17(3), eRB4898. https://doi.org/10.31744/einstein_journal/2019RB4898
13. Sports nutrition market size, share report, 2022-2030. Sports Nutrition Market Size,
Share Report, 2022-2030. (2022). Retrieved April 14, 2022, from
https://www.grandviewresearch.com/industry-analysis/sports-nutrition-market
14. Takahara, T., Amemiya, Y ., Sugiyama, R. et al. Amino acid-dependent control of
mTORC1 signaling: a variety of regulatory modes. J Biomed Sci 27, 87 (2020).
https://doi.org/10.1186/s12929-020-00679-2
15. Wolfe, R.R. Branched-chain amino acids and muscle protein synthesis in humans: myth
or reality?. J Int Soc Sports Nutr 14, 30 (2017).
https://doi.org/10.1186/s12970-017-0184-9
16. Workout supplements. The Nutrition Source. (2021, December 17). Retrieved April 15,
2022, from https://www.hsph.harvard.edu/nutritionsource/workout-supplements/

Back to blog